Table 2.
Most common acute toxicities.
| Toxicity | 5-FU-Based CT Regimen | Capecitabine-Based CT Regimen | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Grade | Grade | |||||||||
| Number of Patients * N = 95 |
1 | 2 | 3 | 4 | Number of Patients * N = 62 |
1 | 2 | 3 | 4 | |
| Hematological toxicities | ||||||||||
| Anemia | 33 | 23 | 8 | 2 | 0 | 11 | 8 | 3 | 0 | 0 |
| Thrombopenia | 50 | 40 | 6 | 4 | 0 | 12 | 7 | 3 | 1 | 1 |
| Neutropenia | 24 | 17 | 4 | 2 | 1 | 6 | 4 | 1 | 1 | 0 |
| Digestive toxicities | ||||||||||
| Diarrhea | 73 | 31 | 35 | 7 | 0 | 47 | 22 | 17 | 8 | 0 |
| Nausea | 27 | 21 | 5 | 1 | 0 | 11 | 8 | 3 | 0 | 0 |
| Anorexia | 28 | 22 | 5 | 1 | 0 | 13 | 7 | 5 | 1 | 0 |
| Vomiting | 6 | 3 | 1 | 2 | 0 | 2 | 1 | 0 | 1 | 0 |
| Rectitis | 43 | 25 | 17 | 1 | 0 | 25 | 15 | 10 | 0 | 0 |
| Anitis | 80 | 28 | 47 | 5 | 0 | 44 | 22 | 19 | 3 | 0 |
| Other toxicities | ||||||||||
| Renal failure | 6 | 5 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Asthenia | 51 | 23 | 22 | 6 | 0 | 26 | 15 | 11 | 0 | 0 |
| Vaginitis | 26 | 17 | 8 | 1 | 0 | 12 | 10 | 1 | 1 | 0 |
| Cystitis | 32 | 24 | 8 | 0 | 0 | 7 | 7 | 0 | 0 | 0 |
| Dermatitis | 77 | 37 | 34 | 6 | 0 | 50 | 31 | 17 | 2 | 0 |
| Alopecia | 20 | 2 | 14 | 4 | 0 | 0 | 0 | 0 | 0 | 0 |
* Some patients experienced more than one toxicity.