Table 1: Workshop Agenda.
Workshop schedule, with talk titles, speakers and key references and background reading.
| NIH Workshop on “Dietary Composition, Time-Restricted Feeding and Associated Metabolic Reprogramming in Healthspan and Longevity Regulation” August 22–23, 2022 | ||
|---|---|---|
| Session 1: Nutrient sensing, macronutrient restriction and dietary composition manipulation in healthspan and longevity regulation | ||
| Talk Title | Speaker | Key References |
| When a calorie is not just a calorie: The regulation of healthy aging by dietary protein and branched-chain amino acids | Dudley Lamming, Ph.D. | 44,69–71,79 |
| Effects of methionine restriction on metabolic and cognitive health | Mirela Delibegovic, Ph.D. | 65 |
| The influence of ketogenic diets on lifespan and healthspan | Jon Ramsey, Ph.D. | 87,89–91 |
| The impact of ketosis on gene expression in multiple tissues of mice | Gino Cortopassi, Ph.D., | 94,95 |
| Session Ila: Interactions between circadian rhythms and dietary interventions in healthspan promotion | ||
| Talk Title | Speaker | Key References |
| Bioenergetics and the Healthful Response to Time Restricted Feeding | Joseph Bass, M.D., Ph.D. | 108 |
| Time-Restricted Feeding and Circadian Mediated Regulation of Age-linked Cardiometabolic Disorders | Girish Melkani, Ph.D. | 110,111,113 |
| Mechanisms of metabolic remodeling during intermittent fasting | Rajat Singh, Ph.D. | 119,120 |
| A dietary molecule as TRF mimetic to promote healthy aging | Zheng Chen, Ph.D. | 101–105 |
| Session Ilb: Interactions between circadian rhythms and dietary interventions in healthspan promotion | ||
| Talk Title | Speaker | Key References |
| Time to live healthier and longer? The tale of mice on Time-Restricted Feeding | Amandine Chaix, Ph.D. | 96–98 |
| Circadian regulation of Drosophila feeding behavior | William Ja, Ph.D. | 116,117 |
| You are when you eat: mechanisms underlying lifespan extension due to intermittent time-restricted feeding in Drosophila | Michele Shirasu-Hiza, Ph.D. | 116 |
| Session III: Macronutrient manipulation in tissue homeostasis and organ function | ||
| Talk Title | Speaker | Key References |
| Influence of diet and nutrient abundance on mammalian intestinal homeostasis | Maria Mihaylova, Ph. D. | 122–124 |
| Branched chain amino acids selectively promote cardiac hypertrophy | Mary Latimer, Ph. D. | 75 |
| Immunometabolic Checkpoints of Inflammation: Lessons from CALERIE | Vishwa Deep Dixit, DVM, Ph. D. | 3,38 |
| Session IV: Translational promises and challenges of dietary interventions to enhance human healthspan | ||
| Talk Title | Speaker | Key References |
| Nutrient and metabolic determinants of human health span—from bench to bedside and back | Anna Thalacker-Mercer, Ph. D. | 82,83 |
| Throwing a Monkey Wrench into Translational Diet Studies | Julie Mattison, Ph. D. | 19,24–27 |
| Opportunities and challenges in incorporating concepts from circadian rhythms and Time-Restricted Eating into lifestyle to increase human healthspan | Satchidananda Panda, Ph.D. | 126–132,134 |