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. Author manuscript; available in PMC: 2024 Sep 1.
Published in final edited form as: Prog Neurobiol. 2023 Jun 23;228:102488. doi: 10.1016/j.pneurobio.2023.102488

Fig. 2. Development of Neutrophils.

Fig. 2.

The figure shows the development of neutrophils in the bone marrow from myeloblast to myelocytes, where C/EBPε expression is increased, and primary granules start to form. These cells develop in close contact with osteoblasts and mesenchymal stem cells (MSC), as they produce CXCL12 that binds to the receptor CXCR4 present on the neutrophil precursors. As the cells further develop, they will become metamyelocytes and then band cells with an increase in expression of Gif-1 and C/EBPβ,ζ, and ζ, with secondary and tertiary granules forming. As band cells, the receptor CXCR2 is upregulated, resulting in the mature neutrophils leaving the bone marrow. The yellow text indicates the order of granule formation, the blue text indicates gene expression, and the black text indicates the order of cell differentiation during development.