Table 3.
Genetic association of six candidate SNPs with fungal sensitivity.
| SNP | Gene | Chr | Location | Allele† | MAF‡ | P value (Odds Ratio) | ||
|---|---|---|---|---|---|---|---|---|
| AAFS vs. AANFS | AAFS vs. NAA | AANFS vs. NAA | ||||||
| rs13431828 | IL1RL1 | 2 | 5' UTR | C/T | 0.13/0.10/0.12/0.13 | 0.42 (1.17) | 0.27 (0.78) | 0.15 (0.75) |
| rs1837253 | TSLP | 5 | Flanking 5' | C/T | 0.22/0.22/0.21/0.26 | 0.64 (0.94) | 0.60 (0.90) | 0.97 (0.99) |
| rs20541 | IL13 | 5 | Missense | G/A | 0.18/0.19/0.21/0.18 | 0.44 (1.12) | 0.25 (1.26) | 0.67 (1.08) |
| rs2395185 | HLA-DRA | 6 | Flanking 3' | G/T | 0.31/0.34/0.39/0.33 | 0.062 (1.26) | 0.017 (1.47) | 0.22 (1.20) |
| rs3939286 | IL33 | 9 | Flanking 5' | C/T | 0.29/0.28/0.31/0.26 | 0.35 (1.13) | 0.43 (1.14) | 0.95 (1.01) |
| rs2872507 | GSDMB | 17 | Flanking 3' | G/A | 0.45/0.45/0.37/0.45 | 0.0099 (0.73) | 0.010 (0.66) | 0.80 (0.97) |
NAA: non-atopic asthma; AANFS: atopic asthma with non-fungal sensitization; AAFS: atopic asthma with fungal sensitization.
†
Allele: Major/Minor allele
‡
MAF: minor allele frequency in 169 NAA, 385 AANFS, 233 AAFS, and ~4,300 general North-Western Europeans from gnomAD V2.1.1 (https://gnomad.broadinstitute.org/).