Figure 6:

Biomarkers of endothelial function were measured in the plasma of mice exposed to filtered air, EPFR lo and EPFR hi. A) The potent vasoconstrictive peptide endothelin-1 (ET-1) was increased in the plasma of mice exposed to EPFR hi versus filter air only. No change in plasma ET-1 levels was noted between mice exposed to EPFR lo versus filtered air (n=16–20/group. B) Nitric oxide (NO) was significantly reduced in the circulation of mice exposed to EPFR hi compared to EPFR lo and filtered air, while mice exposed to EPFR lo did not have significantly altered levels of NO (n=8–14/group). *Indicates p<0.05, **Indicates p<0.01.