Table 6:
Multivariable linear regression of predictor variables and anti-PF4/heparin antibodies
| Trait | Beta [Standard Error] | P-value |
|---|---|---|
| Univariate Regression | ||
| McMaster | ||
| Sex (female) | 0.074 [0.02262] | 0.001 |
| Age (per year) | 0.0016 [0.0007742] | 0.0398 |
| Surgery | 0.082 [0.02829] | 0.00384 |
| Greifswald | ||
| Sex (female) | −0.009 [0.02327] | 0.708 |
| Age (per year) | −0.0005 [0.0008267] | 0.566 |
| Tours | ||
| Sex (female) | 0.434 [0.07069] | 1.30x10−9 |
| Age (per year) | −0.007 [0.002727] | 0.00649 |
| Unfractionated Heparin (vs. LMWH) | −1.515 [0.1516] | <2*10−16 |
| Platelet Count Before Heparin Therapy (1x109 platelets/L) | 0.002 [0.0005177] | 0.000739 |
| Stepwise Regression (Final Model) | ||
| McM aster | ||
| Sex (female) | 0.075 [0.023] | 0.000886 |
| Age (per year) | 0.0017 [0.0007742] | 0.03 |
| Greifswald | ||
| Immunoglobulin A (IgA) | 0.5887 [0.0248] | <2*10−16 |
| Immunoglobulin M (IgM) | 0.3741 [0.0304] | <2*10−16 |
| Tours | ||
| Sex (female) | 0.399 [0.067] | 3.54*10−9 |
| Age (per year) | −0.008 [0.003] | 0.0016 |
| Unfractionated Heparin (vs. LMWH) | −1.462 [0.155] | <2*10−16 |
Association of variables with anti-PF4/heparin antibody levels. Betas (β) and P-values are presented for each variable present in the respective cohorts. For example, surgery status was not available in the Greifswald cohort and as such no regression summary statistics are available for that variable. In each cohort, the model was adjusted for all variable provided in each respective row.