Figure 2.

Pressure-diameter behaviors (mean±SD) of the ascending aorta for all 16 Groups ($n=5$ each, thus representing 80 specimens): female (F) and male (M), wild-type (WT) and Marfan syndrome (MFS) mice without (left) and with (right) BAPN given for 4 weeks beginning either at 4 weeks of age (then evaluated at 8 weeks) or 8 weeks of age (evaluated at 12 weeks of age), with age- and sex-matched controls not receiving BAPN. Qualitatively, BAPN increased aortic dilatation more in MFS than in WT, more in M than F, and more when BAPN was initiated at 4 than 8 weeks of age. These results are not compared statistically since they show a visually interpretable subset of the full data set (namely, circumferential structural data from 1 of the 7 biaxial testing protocols, with only 14 of the over 100 states per protocol per vessel shown for clarity). See Figure S7 for associated circumferential stress-stretch behaviors, and Figures 3, S8 for quantitation and statistical comparisons of the full data sets.