Figure 3.

A-H. Comparison of 8 key geometric and mechanical metrics for the 8 younger Groups: female (F) and male (M), wild-type (WT) and Marfan syndrome (MFS) ascending aortas without (control) or with BAPN given for 4 weeks beginning at 4 weeks of age (then evaluated at 8 weeks). See Figure S8 for similar results when BAPN was started at 8 weeks of age (evaluated at 12 weeks of age). These values (mean±SD) were inferred from ex vivo mechanical testing of excised segments (with $n=5$ per group, 40 aortas tested over the 8 overall groups of younger mice) under physiological conditions, with each mechanical metric calculated from biaxial data from 7 cyclic loading protocols that yielded over 2800 data points per each of the 40 vessels (i.e., comparisons of each metric are based on 112000 on-line computer-controlled measurements). Statistical comparisons by non-parametric Kruskal Wallis test followed by Dunn’s post-hoc test for multiple comparisons; p values < 0.05 indicated.