Figure 4. Schematic summary of study hypothesis and main results. Food restriction, in dissociation with rat nocturnal activity, alters the expression pattern of clock genes in peripheral tissues, such as liver and adipose tissues. These interactions may occur through Sirt1 , a nutrient-sensing gene. BAT: brown adipose tissue; PAT: peri-epididymal adipose tissue; SCN: suprachiasmatic nucleus.