Table 1. Relevant articles founded with the Boolean logic algorithm in the PubMed platform.

Clinicaldata	Sample type	Analytical tool	Cohort	Pathways	Ref
To compare the serum metabolome between GHD patients and healthy controls, and identification of potential markers for diagnosis and/or for individual GH dosing	Serum	GC-MS	10	Lipid and protein metabolism	[( 26 )]
A 17 year old female adolescent with severe GHD secondary to PIT-1 gene mutation. The subject was subsequently followed for 5 years with and without GH therapy	Urine	NMR	1	Beta-oxidation; TCA cycle	[( 27 )]
All patients with short stature were confirmed to be due to the endocrine disorders, especially GH deficiency (GHD)	Serum	NMR	45	Glucose; amino acids	[( 59 )]

GC-MS: gas chromatography mass spectrometry; NMR: nuclear magnetic resonance; TCA cycle: tricarboxylic acid cycle or Krebs cycle.