Table 2.

IQSEC2 vs. RTT comparisons: demographic data.

Variable	A IQSEC2-Mutated Males	B IQSEC2-Mutated Females	C MECP2-Mutated Females	Comparison between Groups (p-Value)	Post Hoc Differences p < 0.05
Demographics
N	9	9	10
Age (years)	10.7 ± 6.6	16.4 ± 7.2	15.5 ± 7.7	0.210
Age category
Pediatric	9 (47.4%)	5 (%)	4 (%)	0.588
Adolescent	6 (31.6%)	3 (%)	3 (%)
Adult	4 (21.1%)	1 (%)	3 (%)
Genetic diagnosis ≤ 2 years
	2 (22.2%)	0 (0%)	8 (80%)	0.0005	C > A ~ B
Body weight z-score	−0.86 ± 1.37	0.42 ± 1.11	−2.00 ± 1.76	0.004	C < B ~ A
Height z-score	−0.49 ± 1.17	−0.16 ± 1.08	−1.90 ± 1.44	0.003	C < B ~ A
Head circumference z-score	−1.23 ± 0.79	−0.65 ± 1.17	−2.3 ± 1.5	0.015	C < B ~ A
BMI z-score	−0.87 ± 1.37	0.24 ± 1.42	−1.26 ± 1.41	0.062
Perinatal/neonatal data
Gestational age (weeks)	40 [38.0–40.2]	38 [37.0–40.0]	40 [40.0–40.0]	0.250
Prematurity	1 (11.1%)	2 (20%)	0 (0%)	0.339
Adverse perinatal events	2 (22.2%)	4 (40%)	1 (10%)	0.289
Neonatal birth weight (g)	3180.0 ± 605.2	3066.8 ± 441.0	3187.0 ± 223.4	0.795
Neonatal birth weight z-score	−0.21 ± 0.93	0.26 ± 1.25	−0.34 ± 0.36	0.379
Birth weight classification
AGA	7 (77.8%)	7 (70%)	9 (90%)	0.698
LGA	1 (11.1%)	2 (20%)	0 (0%)
SGA	1 (11.1%)	1 (10%)	1 (10%)
Delivery mode
SVD	6 (66.7%)	7 (70%)	8 (80%)	0.249
ELCS	2 (22.2%)	0 (0%)	0 (0%)
EMCS	1 (11.1%)	3 (30%)	2 (20%)
Breastfeeding	4 (44.4%)	7 (70%)	10 (100%)	0.025	C < B ~ A
Breastfeeding duration (months)	9.7 ± 5.2	11.3 ± 6.2	10.8 ± 7.2	0.927

Data are expressed as mean ± SD or median [inter-quartile range IQR] as appropriate. Legend: BMI, body mass index; AGA, appropriate for gestational age; LGA, large for gestational age; SGA, small for gestational age; SVD, spontaneous vaginal delivery; ELCS, elective caesarean section; EMCS, emergency caesarean section. Data not available for n = 2 patients. Data not available for n = 1 patient.