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Potential of crosslinked helix fork to target duplex RNA with and without bulges or mismatch base pairing. (CAGCUG)4 represents a fully base paired analog of r(CUG)10. The fluorescence polarization binding assay with CHF-2 provides similar dissociation constant for both RNAs, Kd (CUG)10 = 2.2 ± 0.1 μM; Kd (CAGCUG)4 = 5.9 ± 4.7 μM. Error bars represent the standard deviation of three independent experiments.
