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B‐cell migration. Decrease of CXCR4 caused the migration of B cells from the bone marrow to peripheral blood and an increase of anti‐Aβ antibody, which crossed the blood–brain barrier and entered the cerebrospinal fluid. Antibodies entering cerebrospinal fluid can clear Aβ and activate microglia, further increasing the clearance of Aβ. Aβ, β amyloid; CXCR4, chemokine receptor type 4 [Color figure can be viewed at wileyonlinelibrary.com]
