Table 2.

CXCR4 and CXCL12 in AD

Reference	IF	Object	Intervening measures	Results
Thomas C. Beck et al. (2014)	10.892	B cells	Interrupt the CXCR4 signal	The export of immature B cells from BM is dependent on double downregulation of CXCR4
Yuval Gavriel et al. (2020)	3.517	AD	Combined use of AMD3100 and l‐lactic acid in the treatment of AD	The combined treatment resulted in a significant improvement in cognitive/memory functions and attenuated neuroinflammation
Simona Capsoni et al. (2017)	11.814	AD	Mimic the parenchymal delivery of hNGFp used in clinical trials and intranasal injection of the same dose of hNGFp	2hNGFp acts on glial cells and regulates inflammatory proteins by regulating CXCL12

Note: Research on CXCR4 and CXCL12 over the recent years.

Abbreviations: AD, Alzheimer's disease; BM, bone marrow; CXCL12, CXC motif ligand 12; CXCR4, chemokine receptor type 4; hNGFp, human painless nerve growth factor.