TABLE 1.

Epidemiology and genotypes of GAS isolates

Isolate no.a	Yr/source of isolationb	Disease	M serotype	mrpsc	FAFLP profilesd
SA10	1997/NPH	Cellulitis, septicemia	M77	P1	A1
SA78	1997/NPH	Ulcer	M77	P1	A1
SA800	1997/NPH	Pyrexia, septicemia	M77	P2	A2
SA907	1997/NPH	Wound infection	M77	P2	A2
SA978	1997/NPH	Ulcer	M77	P2	A2
SA1010	1997/NPH	Chest infection	M77	P2	A2
SA1046	1997/NPH	Pyrexia, septicemia	M77	P2	A2
SA1047	1997/NPH	Pyrexia, septicemia	M77	P2	A2
SA1048	1997/NPH	Pyrexia, septicemia	M77	P2	A2
SA1049	1997/NPH	Wound infection	M77	P2	A2
SA512	1997/Whittington Hospital	Fatal septicemia	M77	P3	A3
SA779	1997/Carlisle	Abscess fluid	M77	P4	A4
SA1024	1997/Bury	Septicemia	M77	P5	A5
SA1036	1997/Harold Wood	Pyrexia, septicemia	M77	P6	A6
SA1200	1997/Ireland	Necrotizing fasciitis	M77	P6	A7
SA1393	1997/Cheltenham	Ulcers, septicemia	M77	P6	A8
SA2158	1996/Hull	Septicemia	M77	P6	A9
SA1558	1997/London	Cellulitis	M77	P2	A10
SA2311	1996/Dorchester	Cellulitis	M77	P6a	A11
SA1339	1997/Orpington	Septicemia	M77	P7	A12
SA2321	1996/Birch Hill	Chest infection	M77	P8	A13
SA2367	1996/Surrey	Necrotizing fasciitis	M77	P6	A14
NCTC 12057	1972/Blackpool	Unknown	M77	P9	A15
SA990	1997/Nottingham	Wound infection	M5	P10	A16
SA1050	1997/NPH	Joint pain	M4	P11	A17
SA1051	1997/NPH	Skin infection	M4	P11	A17
SA1052	1997/NPH	Sore throat	M6	P12	A18

^aIsolate numbers were assigned by the Streptococcus and Diphtheria Reference Unit. 

^bNPH, Northwick Park Hospital, London, United Kingdom. Isolates SA10 and SA78 were involved in the first outbreak studied, and isolates SA800, SA907, SA978, SA1010, SA1046, SA1047, SA1048, and SA1049 were involved in the second outbreak studied. 

^cMacrorestriction profiles obtained with SmaI after PFGE. 

^dFAFLP profiles obtained with the EcoRI+0 and MseI+T primer pair.