Table 1.

Association of age at menopause with leukocyte telomere length (in standard deviations of log-transformed leukocyte telomere length) in the UK Biobank and Women’s Health Initiative.

	UK Biobank		Women’s Health Initiative		Meta-analysis
	β (95% CI)	P-value	β (95% CI)	P-value	β (95% CI)	P-value	P(heterogeneity)
Per 5 years of earlier menopause, overall	−0.02 (−0.03 to −0.02)	1.1×10−13	0.00 (−0.01 to 0.02)	7.1×10−1	−0.02 (−0.02 to −0.01)	7.2×10−12	4.0×10−3
Per 5 years of earlier natural menopause	−0.04 (−0.04 to −0.03)	<2.2×10−16	−0.03 (−0.06 to 0.00)	4.7×10−2	−0.04 (−0.04 to −0.03)	<2.2×10−16	5.8×10−1
Per 5 years of earlier menopause, history of gynecologic surgery	−0.02 (−0.03 to 0.00)	2.6×10−2	0.00 (−0.02 to 0.02)	9.3×10−1	−0.01 (−0.02 to 0.00)	5.9×10−2	2.4×10−1
Premature menopausea	−0.03 (−0.07 to 0.00)	3.6×10−2	−0.01 (−0.08 to 0.06)	7.9×10−1	−0.03 (−0.06 to 0.00)	4.4×10−2	5.2×10−1
Natural premature menopausea	−0.08 (−0.13 to −0.03)	1.9×10−3	−0.05 (−0.18 to 0.07)	4.2×10−1	−0.07 (−0.12 to −0.03)	1.4×10−3	7.3×10−1
Surgical premature menopausea	0.00 (−0.04 to 0.04)	9.2×10−1	0.01 (−0.07 to 0.08)	8.8×10−1	0.00 (−0.04 to 0.04)	9.9×10−1	8.5×10−1

Analyses represent linear regression models adjusted for age, age², race/ethnicity, the first ten principal components of genetic ancestry, current/former smoking status, body mass index, diabetes status, current hormone therapy use, and prevalent coronary artery disease. The UK Biobank sample included 112,224 women, of whom 12,531 had a history of gynecologic surgery. The WHI sample included 8,030 women, of whom 3,170 had a history of gynecologic surgery.

^aReference group is women with age at menopause ≥40 years. No corrections for multiple comparisons were made. CI indicates confidence interval.