Table 1.
Demographic, MRI, and CSF Data Based on Clinical Group (n = 85)
| CN (n = 46) |
MCI (n = 27) |
Dementia (n = 12) |
|
|---|---|---|---|
| Age, y | 70.72 (7.38) | 70.99 (7.36) | 73.64 (6.97) |
| Sex | |||
| Female | 33 (71.7) | 18 (66.7) | 6 (50.0) |
| Male | 13 (28.3) | 9 (33.3) | 6 (50.0) |
| Education, y | 15.9 (2.7) | 15.3 (2.3) | 13.9 (3.3) |
| APOE ε4 carrier (n = 74) | 12 (29.3) | 12 (50.0) | 7 (77.8) |
| Thickness of Entorhinal Cortex, mm | 3.39 (0.33) | 3.31 (0.35) | 2.69 (0.59) |
| Thickness of Inferior Parietal Lobule, mm | 2.35 (0.14) | 2.30 (0.15) | 2.24 (0.11) |
| Thickness of Middle Temporal Gyrus, mm | 2.74 (0.13) | 2.68 (0.16) | 2.59 (0.14) |
| Thickness of Parahippocampal Gyrus, mm | 2.69 (0.24) | 2.66 (0.23) | 2.39 (0.44) |
| Thickness of Posterior Cingulate, mm | 2.38 (0.12) | 2.31 (0.14) | 2.23 (0.08) |
| Thickness of Insula, mm | 2.80 (0.14) | 2.72 (0.18) | 2.65 (0.18) |
| Thickness of Precuneus, mm | 2.29 (0.13) | 2.25 (0.12) | 2.22 (0.11) |
| Volume of Hippocampus, mm3 | 7308.60 (692.98) | 6905.53 (923.82) | 6032.70 (968.35) |
|
Volume of WMH, mL (n = 78) |
6.24 (9.78) | 9.57 (16.41) | 15.56 (11.82) |
|
Log-transformed Volume of WMH (n = 78) |
0.30 (0.69) | 0.58 (0.66) | 1.06 (0.40) |
|
CSF Aβ1–42, pg/mL (n = 48) |
1325.50 (744.50) | 1075.18 (591.82) | 583.68 (219.32) |
|
CSF t-tau, pg/mL (n = 48) |
193.98 (110.16) | 233.61 (111.32) | 408.18 (199.76) |
|
CSF p-tau, pg/mL (n = 48) |
18.05 (11.43) | 22.52 (11.91) | 40.69 (20.49) |
All continuous data reported as mean (SD), categorical data (sex, APOE ε4 carrier) reported as number (percent).
Abbreviations: Aβ1–42 = amyloid beta 1–42 peptide ; APOE = apolipoprotein E; CN = cognitively normal; CSF = cerebrospinal fluid; MCI = mild cognitive impairment; MRI = magnetic resonance imaging; p-tau = phosphorylated tau; SD = standard deviation; t-tau = total tau; WMH = white matter hyperintensities