Table 3.
Post Hoc Tukey’s HSD Test for MRI Measures (n = 85)
| t ratio, p value 95% CI | ||||
|---|---|---|---|---|
| Variables | ANCOVA Model, p value | CN-Dementia | CN-MCI | MCI-Dementia |
| Thickness of Entorhinal Cortex | F(3,81) = 14.06, p <0.001 | −5.42, <0.001 [−0.94 – −0.37] | - | −4.51, <0.001 [−0.89 – −0.27] |
| Thickness of Middle Temporal | F(3,81) = 9.45, p <0.001 | −2.89, 0.01 [−0.22 – −0.02] | - | - |
| Thickness of Parahippocampal | F(3,81) = 4.07, p = 0.01 | −3.18, 0.006 [−0.50 – −0.07] | - | −2.75, 0.02 [−0.49 – −0.03] |
| Thickness of Posterior Cingulate | F(3,81) = 6.48, p = 0.001 | −3.45, 0.003 [−0.23 – −0.04] | 2.49, 0.04 [0 – 0.14] | - |
| Thickness of Insula | F(3,81) = 9.20, p <0.001 | −2.71, 0.02 [−0.24 – −0.02] | - | - |
| Volume of Hippocampus | F(3,81) = 13.38 p <0.001 | −4.65, <0.001 [−1750.17 – − 563.04] | - | −2.88, 0.01 [−1398 – − 130.6] |
|
Log-transformed Volume of WMH (n = 78) |
F(4,73) = 7.15, p <0.001 | 2.84, 0.02 [0.10 – 1.13] | - | - |
Only regions with significant clinical group differences (p < 0.05) following post hoc Tukey’s HSD test shown. Age was added as a covariate in all models. Acquisition type was also added as a covariate in volume of WMH model.
Abbreviations: ANCOVA = analysis of covariance; CN = cognitively normal; HSD = honestly significant difference; MCI = mild cognitive impairment; MRI = magnetic resonance imaging; WMH = white matter hyperintensities