Table 2:
The [77Br]RD1 toxicological EC50 values of the various ovarian cancer cell lines and their corresponding 95% CI.
| Ovarian | Molar Concentration (nM) | Activity Concentration (10−2 MBq/mL) | Cellular Activity Uptake (10−2 Bq/cell) | Nuclear Dose (Gy) |
|---|---|---|---|---|
| Cancer Cell Line | EC50 95% CI | EC50 95% CI | EC50 95% CI | D 50 |
| ID8 | 2.3 (1.8–2.9) | 44 (36–53) | 3.9 (3.3–4.6) | 9.2±1.0 |
| OVCAR8 | 0.17 (0.13–0.24) | 7.0 (6.2–8.0) | 1.8 (1.6–2.0) | 4.3±0.3 |
| OVCAR8 PARP1-KO | 0.46 (0.34–0.62) | 20 (15–28) | 2.0 (1.5–2.7) | 3.4±0.6 |
| UWB1.289 | 0.27 (0.21–0.36) | 6.1 (4.4–8.6) | 2.7 (2.0–3.7) | 3.9±0.8 |
| UWB1.289+BRCA1 | 0.30 (0.22–0.41) | 6.8 (5.5–8.3) | 2.3 (1.9–2.8) | 3.3±0.4 |