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. Author manuscript; available in PMC: 2024 Aug 1.
Published in final edited form as: Hippocampus. 2023 Apr 24;33(8):970–992. doi: 10.1002/hipo.23541

FIGURE 10.

FIGURE 10

Cross frequency coupling (CFC) in eFSE animals is altered by depth. (a)–(c) Modulation index of CA1 and DG regions of interest for slow gamma, medium gamma, and fast oscillations (120–200 Hz). In CTL rats, LFPs during tail pinch exhibit significant CFC with slow gamma oscillations at SR and fast oscillations at SP. In eFSE animals, CFC of gamma and fast oscillations during TPS is significantly attenuated at SR and SP. (d) From Figure 9d, averaged modulation index for 2.25–5.25 Hz phase frequency in CTL (di) and eFSE animals (dii). As averaging across bandwidths can miss key details about frequency tuning, the modulation index for 2.25–5.25 Hz was analyzed across 25–200 Hz amplitude frequencies via GEE. (e) Rats with eFSE exhibit attenuated CFC across gamma bandwidths at SP, SR, and OML. (f) The CTL rat pattern of differential CFC at OML and MML synapses relative to slow and medium gamma is contrasted by eFSE downward shifts in CFC at the same 25 Hz frequency.