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. Author manuscript; available in PMC: 2024 Jul 19.
Published in final edited form as: ACS Chem Neurosci. 2023 Jul 3;14(14):2569–2581. doi: 10.1021/acschemneuro.3c00268

Table 3.

Significantly changing prohormone-derived hypothalamus peptides identified from the Oct. (Tb = 21-35 °C) vs. Aug. (Active) comparison.

Peptide Sequencea Peptide Nameb Gene FC(log2)c
Q(−17.03)EDAELQP CARTPT 3.50
Q(−17.03)EDAELQPR CARTPT 2.50
FLGEAYHHVPESQ CHGB 2.19
FLGEAYHHVPESQRD CHGB 2.20
LGVLFNPYYDPLQWKSSRFE CHGB 1.15
Q(−17.03)YDRVAELDQLLHY BAM-1745 CHGB 0.92
SSPETLISDLLMRESTENVPRTRLEDPSMW C-terminal flanking peptide NPY 2.52
YPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRY(−.98) Neuropeptide Y NPY 3.46
AADQDLGPEAPPEGVLGA PEN-18 PCSK1N 1.91
AADQDLGPEAPPEGVLGAL PEN-19 PCSK1N 1.96
AADQDLGPEAPPEGVLGALL PEN-20 PCSK1N 1.36
AADQDLGPEAPPEGVLGALLRV PEN PCSK1N 1.59
LENPQPQAPA LittleLEN PCSK1N 2.61
LENPQPQAPARRLLPP BigLEN PCSK1N 2.16
SLSAASPPMTEAGTPRRF LittleSAAS PCSK1N 1.78
SVPRGEAAGAVQELARALAHLLEAERQE BigGAV PCSK1N 1.57
VKMALQQEGFD PCSK2 1.14
YGGFLRKYP β-neoendorphin PDYN 2.33
YGGFLRKYPK α-neoendorphin PDYN 1.70
MDELYPVEPEEEANGGEVL PENK 1.70
MDELYPVEPEEEANGGEVLA PENK 1.48
SPQLEDEAKEL PENK 1.77
SPQLEDEAKELQ PENK 2.05
VGRPEWWMDYQ PENK 1.45
YGGFMRF Met-enkephalin-Arg-Phe PENK 2.09
YGGFMRGL Met-enkephalin-Arg-Gly-Leu PENK 2.14
EIGDEENSAKFPI(−.98) Neuropeptide-glutamic acid-isoleucine PMCH 1.44
ALNSVAYERNAMQNYE C-terminal flanking peptide TAC1 2.21
RPKPQQFFGLM(−.98) Substance P TAC1 1.54
ASWTREPLE TRH 2.51
ASWTREPLEE TRH 2.36
EDEAAWSLDRTQQ TRH 2.74
a

Post-translational modifications are indicated by mass change observed by mass spectrometry. Amidation = (−.98), pyroglutamylation = (−17.03).

b

Peptide common names inferred from analogy to well-annotated rat sequence.

c

Fold-change values are given for Oct./Aug. comparison. A positive value indicates the peptide is higher abundance in Oct.