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. Author manuscript; available in PMC: 2024 Oct 15.
Published in final edited form as: Am J Cardiol. 2023 Sep 4;205:451–453. doi: 10.1016/j.amjcard.2023.07.177

Figure 1: Association of B-Type Natriuretic Peptide with Study Outcomes in Continuous Flow Left Ventricular Assist Device Recipients.

Figure 1:

Panel 1: Kaplan Meier Failure Curves Depicting the Cumulative Incidence of Study Outcomes Stratified by the Quartiles of B-Type Natriuretic Peptide

The cumulative incidence curves for long-term mortality, cardiovascular mortality, right heart failure, and arrhythmia stratified by the quartiles of B-type natriuretic peptide (BNP) have been depicted. Quartiles 1, 2, 3, and 4 of BNP have been presented in blue, red, green, and brown, respectively.

Panel 2: Non-Linear Association of B-Type Natriuretic Peptide with Study Outcomes

The figure represents the non-linear association of B-type natriuretic peptide (BNP) with long-term mortality, cardiovascular mortality, arrhythmia, and right heart failure. Restricted cubic spline modeling adjusted for age, sex, race/ethnicity, body mass index, INTERMACS profile, estimated glomerular filtration rate (2021 CKD-EPI creatinine equation), implantation year, device strategy, employment status, education level, and volume of the center at which the device was implanted was used to demonstrate the non-linear association of BNP and study outcomes.

Panel 3: Association of B-Type Natriuretic Peptide Levels with Study Outcomes

Multivariable-adjusted Cox proportional hazard regression models were used to assess the risk of the study outcomes which accounted for age, sex, race/ethnicity, body mass index, INTERMACS profile, estimated glomerular filtration rate (2021 CKD-EPI creatinine equation), implantation year, device strategy, employment status, education level, and volume of the center at which the device was implanted. The Cox model for peri-operative mortality was additionally adjusted for extra-corporeal membrane oxygenation use in the past 48 hours, intra-aortic balloon pump use in the past 48 hours, intravenous inotrope use, right atrial pressure, and pulmonary capillary wedge pressure. The first, second, third, and fourth quartiles of BNP are presented in black, red, blue, and green, respectively.