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. 2023 Aug 23;45(9):7011–7026. doi: 10.3390/cimb45090443

Figure 3.

Figure 3

Induction of cell cycle arrest, gene expression, and protein degradation in AML cells treated with HSP90 inhibitor PU-H71 (PU). Cytometric analysis of AML cell lines MOLM13 (A), OCI-AML3 (B), and SKM-1 (C) after 20 h treatment with 100–300 nM PU-H71. According to DAPI staining, cell intensities were classified as the G0/G1 (2N) or G2 (4N) phase. Relative quantitation of CDKN1A (D) and TP53 (E) gene expression. Relative quantitation of FLT3, BCL2, and MCL1 protein levels in MOLM-13 cells treated with 100–200 nM PU-H71 (F). Significance of differences denoted for p < 0.01 (**); p < 0.001 (***); and p < 0.0001 (****).