TABLE 1.

Risk Stratification of Pediatric and Young Adult Germ Cell Tumors^8,9,32,34

Risk Group	Age (y)	Site	COG Stage	IGCCCG (if applicable)		Predicted LTDF Survival (%)	95%CI (%)
LR	0–15 0–16 Any	Testicular Ovarian Extragonadal	I I I		100* 96* unknown**		- 74–99 -
SR1	<11 <11 <11 <11 <11 <11	Testicular Ovarian Testicular Ovarian Extragonadal Extragonadal	II-III II-III IV IV II-III IV		99 97 96 92 91 79		96–100 93–99 91–99 83–96 86–94 71–84
SR2	≥11 ≥11 ≥11 ≥11	Testicular Ovarian Testicular Extragonadal	II-III II-III IV II	Good	93 85 83 65		84–97 77–91 67–91 48–78
PR	≥11 ≥11 ≥11 ≥11 ≥11	Extragonadal Testicular Testicular Ovarian Extragonadal	III II-IV II-IV IV IV	Intermediate Poor	65 75# 41# 67 40		48–78 71–79 35–47 49–80 24–56

Abbreviations: y, years; COG, Children’s Oncology Group; IGCCCG, International Germ Cell Cancer Collaborative Group;

MaGIC, Malignant Germ Cell International Consortium; LTDF, Long-term disease free survival; CI, Confidence Interval; LR, Low Risk; SR1, Standard Risk 1; SR2, Standard Risk 2; PR, Poor Risk

^*4 year Overall Survival used here

^**Currently being explored in COG AGCT 1531

^#5 year Event Free Survival used here

Bold Font: Risk Group, Age (y), Site, COG Stage, IGCCCG (if applicable), Predicted LTDF Survival (%), 95% CI (%)