Table 3.

Primary and secondary outcomes associated with CRT for patients with and without a history of AF

	Estimate	95% Credible interval	Posterior probability
Time to all-cause mortality or HFH
HR for CRT overall†	0.69	0.56 – 0.81	< 0.001
By AF status¥
HR for CRT in history of AF	0.78	0.55 – 1.10	0.17
HR for CRT in no history of AF	0.67	0.55 – 0.80	<0.001
Ratio of hazard ratios (History of AF/No AF)	1.17	0.83 – 1.64	0.26
	Estimate	95% Credible interval	Posterior probability
Time to all-cause mortality
HR for CRT overall†	0.82	0.66 – 1.01	0.067
By AF status¥
HR for CRT in history of AF	1.09	0.70 – 1.74	0.70
HR for CRT in no history of AF	0.76	0.60 – 0.97	0.024
Ratio of hazard ratios (History of AF/No AF)	1.45	0.89 – 2.27	0.14

The hazard rate for each outcome in AF subgroups with CRT compared to no CRT. All models are adjusted for age, sex, NYHA class, ejection fraction, QRS width, presence of LBBB, diabetes, hypertension, ischemic etiology, use of antiarrhythmic drugs, use of beta-blockers, use of angiotensin-converting enzyme inhibitor or angiotensin receptor blocker, and the presence of an ICD

^†Estimates obtained from model with an overall CRT effect.

^¥Estimates obtained from a model CRT effect by AF status (that is a model with an interaction between CRT and AF).

AF: atrial fibrillation, CRT: cardiac resynchronization therapy, HFH: heart failure hospitalization, HR: hazard ratio.