Table 1:

Disorders linked to mechanical platelet dysfunction

Disorder	Platelet Mechanical Insights	Reference
Sickle Cell Disease	Decreased bulk contraction force	(103)
Asthma	Decreased bulk contraction force	(104)
Lupus	Decreased bulk contraction force	(105)
Acute ischemic stroke	Decreased bulk contraction force	(106)
Covid-19	Decreased bulk contraction force	(114)
Trauma	Decreased aggregate and bulk contraction force	(99) (107)
Thromboangiitis obliterans	Increased bulk contraction force	(109)
Polycythemia Vera	Increased bulk contraction force	(110)
Severe coronary artery disease	Increased bulk contraction force	(111)
Chest pain associated coronary artery disease	Increased bulk contraction force and increased clot elastic modulus	(112)
May Hegglin Disorder	Decreased single platelet contractile force	(74, 113)
Wiskot Aldrich Syndrome	Decreased single platelet contractile force	(74)
Symptomatic Bleeding	Decreased single platelet contraction force	(74)
type 2B von Willebrand’s Disease	Enhanced mechanical activation of GP1b leading to platelet clearance	(49)
Glanzmann’s thrombasthenia	Impaired platelet adhesion to fibrinogen	(67, 68)
Bernard-Soulier syndrome	Impaired adhesion to vWF	(47)
GPVI deficiency	Impaired platelet response to collagen	(115)
α2β1 deficiency	Impaired platelet response to collagen	(83)