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. Author manuscript; available in PMC: 2024 Oct 1.
Published in final edited form as: Trends Biochem Sci. 2023 Aug 12;48(10):839–848. doi: 10.1016/j.tibs.2023.07.009

Figure 1. Sharp and broad promoter architectures.

Figure 1.

UCSC browser genomic CAGE snapshots of the human TATA/DPE containing CALM2 and VEGFA promoters (A) and the TATA-less TAF7 and AKT1 promoters (B). CALM2 and TAF7 have been analyzed structurally by [31]. The CAGE mapped main TSS of the TATA-containing promoters (A) and the multiple mapped TSSs of the TATA-less promoters (B) are indicated with arrows showing the direction of Pol II transcription. The interval of All ENCODE CAGE tag densities (All CAGE) for each gene, on either forward (+) or reverse (−) strands, are indicated on the left. TATA or TATA-like elements (boxed in green), downstream promoter elements (DPEs, including its consensus sequence, are boxed in khaki) and alternative DPE-like sequences (transparent khaki boxes) are indicated. In A) DBS is highlighted (see text).