Table 2:

Outcomes by Early Antibiotic Exposure Status

Outcome	Overall cohort  (n=88,574)	Antibiotic exposure days 0–2  (n= 75,353)	No antibiotic exposure days 0–2  (n= 13,221)	p-value
Outcomes during days 3–7
LOI	1,437 (1.6%)	1,154 (1.5%)	283 (2.1%)	<0.001
NEC/SIP	1,398 (1.6%)	1,290 (1.7%)	108 (0.8%)	<0.001
Death	1,726 (1.9%)	1,566 (2.1%)	160 (1.2%)	<0.001
Composite: LOI + death	3,055 (3.4%)	2,633 (3.5%)	422 (3.2%)	0.08
Age at death for those dying on days 3–7, (median [IQR])	5 [3 – 6]	5 [3 – 6]	4 [3 – 6]	0.12
Outcomes after day 7
LOI after day 7	9,834 (11%)	8,916 (12%)	918 (7%)	<0.001
NEC after day 7	5,680 (6%)	5,099 (7%)	581 (4%)	<0.001
Death after day 7, prior to NICU discharge	4,840 (6%)	4,518 (7%)	322 (3%)	<0.001
Age at death (days) for those dying after 7 days, (median [IQR])	21 [13 – 39]	21 [13 – 39]	21 [12 – 35]	0.23