Table 5:
Organism Distribution among Patients with LOI
| n (%) | By Antibiotic Exposure Group, n (%) | |||
|---|---|---|---|---|
| Organism | Overall Cohort (n = 1,450 isolates in LOI) |
Antibiotic exposure days 0–2 (n = 1,164 isolates in LOI) |
No antibiotic exposure days 0–2 (n = 286 isolates in LOI) |
P-value |
| Gram-positive | 768 (53%) | 569 (49%) | 199 (70%) | <0.001 |
| Coagulase-negative Staphylococcus | 427 (29%) | 367 (32%) | 60 (21%) | |
| Staphylococcus aureus | 174 (12%) | 71 (6%) | 103 (36%) | |
| Enterococcus spp. | 35 (2%) | 20 (2%) | 15 (5%) | |
| Gram-positive cocci, not speciated | 127 (9%) | 108 (9%) | 19 (7%) | |
| Group B Streptococcus | 4 (<1%) | 3 (<1%) | 1 (<1%) | |
| Clostridia | 1 (<1%) | 0 (0%) | 1 (<1%) | |
| Gram-negative | 524 (36%) | 443 (38%) | 81 (28%) | 0.002 |
| E. coli | 236 (16%) | 217 (19%) | 19 (7%) | |
| Klebsiella | 80 (6%) | 62 (5%) | 18 (6%) | |
| Enterobacter | 34 (2%) | 20 (2%) | 14 (5%) | |
| Pseudomonas | 33 (2%) | 29 (3%) | 4 (1%) | |
| Citrobacter | 15 (1%) | 11 (1%) | 4 (1%) | |
| Acinetobacter | 9 (1%) | 6 (1%) | 3 (1%) | |
| Serratia | 18 (1%) | 15 (1%) | 3 (1%) | |
| Proteus | 5 (<1%) | 3 (<1%) | 2 (1%) | |
| Haemophilus influenzae | 3 (<1%) | 3 (<1%) | 0 (0%) | |
| Stenotrophomonas | 3 (<1%) | 2 (<1%) | 1 (<1%) | |
| Neisseria | 1 (<1%) | 1 (<1%) | 0 (0%) | |
| Gram-negative rod, not speciated | 87 (6%) | 74 (6%) | 13 (5%) | |
| Fungi (all Candida) | 124 (9%) | 123 (11%) | 1 (<1%) | <0.001 |
| Other | 34 (2%) | 29 (3%) | 5 (2%) | 0.46 |
Footnote: The number of organisms isolated overall (1,450) is higher than the number of total LOI episodes (1,437), as a small number of infants had >1 organism isolated at the time of LOI diagnosis.