Table 1.
Descriptive statistics of all the study samples.
| Study design | Cross- sectional |
Cross- sectional |
Longitudinal | Longitudinal |
|---|---|---|---|---|
| Available statistics | Correlation available |
Corrected correlation available |
TL yearly change rate available |
TL yearly -score change rate available |
| Number of study samples | 341 | 286 | 73 | 49 |
| Number of subjects | 720,078 | 626,744 | 22,941 | 20,276 |
| Number of males | 335,093 | 293,070 | 10,820 | 9,743 |
| Number of females | 383,418 | 333,168 | 11,560 | 10,529 |
| Age range (years) | 0-112 | 0-112 | 0-97 | 0-94 |
| Follow-up duration (years)‡ | / | / | 7 (1-41) | 6 (1-41) |
| Sex included† | ||||
| Only males | 43 (12.6%) | 38 (13.3%) | 17 (23.3%) | 9 (18.4%) |
| Only females | 48 (14.1%) | 39 (13.6%) | 16 (21.9%) | 8 (16.3%) |
| Both males and females | 233 (68.3%) | 200 (69.9%) | 38 (52.0%) | 31 (63.3%) |
| Not reported | 17 (5.0%) | 9 (3.2%) | 2 (2.7%) | 1 (2.0%) |
| Health status† | ||||
| Healthy | 141 (41.4%) | 121 (42.3%) | 16 (21.9%) | 12 (24.5%) |
| General population | 112 (32.8%) | 93 (32.5%) | 53 (72.6%) | 33 (67.4%) |
| CVDs | 25 (7.3%) | 24 (8.4%) | 1 (1.4%) | 1 (2.0%) |
| Cancer | 51 (15.0%) | 36 (12.6%) | 1 (1.4%) | 1 (2.0%) |
| Depression/Anxiety/PTSD | 12 (3.5%) | 12 (4.2%) | 2 (2.7%) | 2 (4.1%) |
| TL measurement method† | ||||
| Southern blot | 76 (22.3%) | 56 (19.6%) | 23 (31.5%) | 11 (22.4%) |
| qPCR | 248 (72.7%) | 216 (75.5%) | 50 (68.5%) | 38 (77.6%) |
| qFISH | 12 (3.5%) | 9 (3.2%) | 0 (0%) | 0 (0%) |
| Flow FISH | 5 (1.5%) | 5 (1.8%) | 0 (0%) | 0 (0%) |
| Tissue type used for TL measurement† | ||||
| Blood leukocytes | 262 (76.8%) | 222 (77.6%) | 47 (64.4%) | 38 (77.6%) |
| Dry blood spots | 4 (1.2%) | 4 (1.4%) | 2 (2.7%) | 0 (0%) |
| PBMCs | 50 (14.7%) | 37 (12.9%) | 16 (21.9%) | 3 (6.1%) |
| Saliva | 14 (4.1%) | 14 (4.9%) | 7 (9.6%) | 7 (14.3%) |
| Buccal cells | 11 (3.2%) | 9 (3.2%) | 1 (1.4%) | 1 (2.0%) |
| DNA extraction procedure† | ||||
| Salting out | 65 (19.1%) | 59 (20.6%) | 23 (31.5%) | 21 (42.9%) |
| Silica membrane column | 90 (26.4%) | 76 (26.6%) | 32 (43.8%) | 12 (24.5%) |
| Magnetic bead | 15 (4.4%) | 14 (4.9%) | 1 (1.4%) | 1 (2.0%) |
| Phenol-chloroform | 18 (5.3%) | 14 (4.9%) | 1 (1.4%) | 1 (2.0%) |
| Anion exchange | 1 (0.3%) | 1 (0.4%) | 0 (0%) | 0 (0%) |
| Not reported | 152 (44.6%) | 122 (42.7%) | 16 (21.9%) | 14 (28.6%) |
CVD, cardiovascular disease; PTSD, post-traumatic stress disorder; qPCR, quantitative polymerase chain reaction; qFISH, quantitative fluorescence in situ hybridization; PBMC, peripheral blood mononuclear cells.
†
Data are presented as number of study samples (percentage)
‡
Data are presented as median (range)