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. 2023 Sep 27;18(9):e0292157. doi: 10.1371/journal.pone.0292157

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© 2023 Carvelli et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 2 — EM of seminiferous epithelium (SE) of WT (A, B) and KO (C-F) KO tubules at 11 or 14 months of age. In (A, B), tubules reveal a close approximation of germ cells with Sertoli cells (S), small dense lysosomes (arrowheads) and intact BTB (curved arrows). In (C), abnormally large and medium-sized dense granulated lysosomes (Ly) are prominent in SE, as well as large lipid droplets (Li). In (D), numerous small lysosomes (arrowheads) occupy the base of Sertoli cells, along with a large myelinated-like body (mye). In (C), Sertoli cells reveal an intact BTB (curved arrows), while in (D-F), it is disrupted. In (D-F), Sertoli cells show abnormal bloated basal and adluminal compartments resulting in dilated intercellular spaces (ICS) confluent with the cytoplasm (cyt) and containing organelles and membranous profiles. Germ cells: spermatogonia (SG), early (ES) and late (LS) spermatids; pachytene (PA) and preleptotene (PL) spermatocytes; zygotene (Z) spermatocytes; As, acrosome; BM, basement membrane; My, myoid cells; N, Sertoli cell nucleus. Scale bars = 2 μm.