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. Author manuscript; available in PMC: 2024 Sep 21.
Published in final edited form as: Cell Chem Biol. 2023 Jun 23;30(9):1144–1155.e4. doi: 10.1016/j.chembiol.2023.06.001

Figure 2: Downregulation of one-carbon metabolism genes is a common signature between NREP silencing in primary human hepatocytes and human NAFLD.

Figure 2:

(A) Venn diagram of intersected genes between NREP knock-down (KD) versus Scramble and Steatosis versus Control patients reanalyzed from 31. (B) Pathway enrichment analyses on commonly upregulated genes between NREP KD versus Scramble and Steatosis versus Control patients. (C) Pathway enrichment analyses on commonly downregulated genes between NREP KD versus Scramble and Steatosis versus Control patients. (D) Heat-map of represented pathways and genes commonly altered between NREP KD versus Scramble and Steatosis versus Control patients. (E) Venn diagram of intersected genes between NREP KD versus Scramble and Steatohepatitis versus Control patients downloaded and reanalyzed from 31. (F) Pathway enrichment analyses on commonly upregulated genes between NREP KD versus Scramble and Steatohepatitis versus Control patients. (G) Pathway enrichment analyses on commonly downregulated genes between NREP KD versus Scramble and Steatohepatitis versus Control patients. (H) Heat-map of represented pathways and genes commonly upregulated genes between NREP KD versus Scramble and Steatohepatitis versus Control patients. (I) Pearson’s correlations between NREP and represented one-carbon metabolism genes in controls and Steatosis. (J) Pearson’s correlations between NREP and represented one-carbon metabolism genes in Controls and Steatohepatitis. Statistical analyses by the Benjamini-Hochberg method (see Methods). All represented genes with FDR<0.05 (our RNA-seq dataset) or P<0.05.