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Synthesis of 2-chloro-1-(5-(2-methylthiazol-4-yl)indolin-1-yl)ethan-1-one (97*). Reagents and conditions: A: a) nBuLi, Et2O, −78 °C, 4h; Me2SO4, −78 °C, overnight; B: b) Boc2O, DMAP, MeCN, rt, 1h; c) B2pin2, Pd(dppf)Cl2, KOAc, DMSO, 80°C, overnight; C: d) Pd2(dba)3, xPhos, Cs2CO3, dioxane, H2O, 80 °C, overnight; e) TFA, DCM, rt, 1h, f) chloroacetyl chloride, Et3N, DCM, 0°C, 1h.
