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Synthesis of 7-bromo-4-(2-chloroacetyl)-1-methyl-3,4-dihydroquinoxalin-2(1H)-one (1269*). Reagents and conditions: a) EDC hydrochloride, DCM, rt, 1h; b) NaNO2, H2SO4, O2, MeCN, rt, overnight; c) Na2S2O4, EtOH, H2O, reflux, 2h; d) NaBH4, THF, reflux, 30 min. e) chloroacetyl chloride, Et3N, DCM, 0 °C to rt, 1h.
