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. Author manuscript; available in PMC: 2024 Aug 17.
Published in final edited form as: Cell Chem Biol. 2023 Jun 29;30(8):879–892.e5. doi: 10.1016/j.chembiol.2023.06.007

Figure 4. Sequence differences between selected sgRNAs and WT sgRNA.

Figure 4.

The divergence of 647 selected cleavage-capable variant sgRNAs is shown compared to the WT sgRNA sequence. Positions where the base does not change from WT (“native”) are shown in black. Changes in base identify from the WT sequence are shown in color as indicated. Certain variants have an additional nucleotide between positions 71 and 72 or 73 as marked in gray