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. Author manuscript; available in PMC: 2024 Sep 15.
Published in final edited form as: Circ Res. 2023 Aug 22;133(7):611–627. doi: 10.1161/CIRCRESAHA.123.322562

Figure 4. α2δ−1–bound NMDARs are responsible for the increased glutamatergic input to PVN presympathetic neurons by calcineurin inhibition.

Figure 4.

A-C, Original recording traces and cumulative probability plots (A and B) and quantification (C) show the effects of bath application of AP5 (50 μM) on miniature of excitatory postsynaptic currents (mEPSCs) in labeled PVN neurons in brain slices pretreated with 1 μM control (Ctrl) peptide or 1 μM α2δ−1 C terminus peptide (α2δ−1CT peptide) in FK506-treated rats (n = 10 neurons from 4 male rats per group). D, Representative recording traces and quantification show effects of pretreatment with 1 μM Ctrl peptide or 1 μM α2δ−1CT peptide on the amplitude of puff-elicited NMDAR currents in labeled PVN neurons in brain slices from FK506-treated rats (n = 10 neurons from 4 male rats per group). The repeated measures models were fitted for statistical analysis.