Table 4. One-Year Bleeding Rates by Risk Category for Individuals in the Development & Validation Cohorts.

Presented are 1-year bleeding rate estimates for individuals in the development and validation cohorts. Event counts are based on one-year censoring. Risk categories were assigned by the DOAC Score based on risk score. Each individual could be assigned a risk score from 0-10, with the following risk categories: very low (score 1-3), low (score 4-5), moderate (score 6-7), high (score 8-9) and very high (score 10).

	RE-LY (N=5684)		GARFIELD-AF (N=12,296)		COMBINE-AF (N=25,586)		RAMQ (N=11,945)
Risk Category (Risk Score)	N (Major Bleeding Events)	1-Year Rate	N (Major Bleeding Events)	1-Year Rate	N (Major Bleeding Events)	1-Year Rate	N (Major Bleeding Events)	1-Year Rate
Very Low (0-3)	767 (2)	0.8%	4360 (14)	0.3%	6038 (82)	1.5%	1832 (10)	0.6%
Low (4-5)	1249 (21)	1.6%	3735 (33)	0.9%	6630 (123)	2.0%	2834 (40)	1.4%
Moderate (6-7)	1727 (53)	3.4%	3263 (60)	1.9%	7348 (197)	3.1%	3418 (72)	2.1%
High (8-9)	1296 (87)	6.9%	748 (17)	2.4%	4015 (188)	5.4%	2274 (76)	3.3%
Very High (10)	645 (73)	13.9%	190 (7)	3.7%	1555 (102)	7.7%	1587 (60)	3.7%