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. 2023 Oct 1;14(5):1651–1676. doi: 10.14336/AD.2023.0208

Figure 4.

Figure 4.

Rejuvenation strategies of MSC senescence. The main rejuvenation strategies for MSC senescence include epigenetic modification, primarily by regulating noncoding RNAs (miRNAs, lnRNAs, circRNAs); drugs and small molecules; physiological preconditioning (by changing oxygen content and temperature during cell culture, etc.); tissue engineering (by modifying cells nurturing environment). miRNAs, microRNAs; lncRNAs, long noncoding RNAs; circRNAs, circular RNAs; 5-MTP, 5-methoxytryptophan; FGF, fibroblast growth factor; IGF, insulin-like growth factor; NDNF, neuron-derived neurotrophic factor; MIF, migration inhibitory factor.