Inhibition of miR-195 |
BM-MSC |
Target to 3'-untranslated region of TERT gene |
Telomere relengthening |
[115] |
Overexpression of miR-141-3p |
UCB-MSC |
Target to ZMPSTE24 |
Upregulate prelamin A |
[116] |
Inhibition of miR-34a |
BM-MSC |
Target to TP53 |
Reduce ROS |
[117] |
Inhibition of miR-155 |
BM-MSC |
Target to Bcl-2 associated BAG5 |
Enhance mitophagy |
[118] |
Inhibition of miR-199a-5p |
AD-MSC |
Target to the SIRT1/AMPK signaling pathway |
Promotes autophagy and ameliorates MSC senescence |
[119] |
Inhibition of miR-155-5p |
BM-MSC |
Target to the AMPK signaling pathway |
Rejuvenate aged MSC |
[28] |
Overexpression of miR-10a |
BM-MSC |
Target to the BAX/Bcl-2 pathway |
Rejuvenate aged MSC and improved cardiac function |
[120] |
Inhibition of miR-29c-3p |
BM-MSC |
Target to CNOT6 through p53-p21 and p16-pRB pathways |
Rejuvenate osteogenic differentiation capacity of senescent MSC |
[121] |
Overexpression of miR-20b-5p/miR-106a-5p |
WJ-MSC |
Target to the p21/CDK/E2F1 pathway |
Promote cell proliferation, G1/S transition and DNA synthesis of MSC |
[122] |
Inhibition of miR-196a |
BM-MSC |
Target to HOXB7 |
Improve proliferation and osteogenesis |
[123] |
Overexpression of miR-130b |
BM-MSC |
Target to the ERK/FOXM1 pathway |
Against HG-induced MSC senescence |
[124] |
Inhibition of miR-483-3p |
AD-MSC |
Target to insulin-like growth factor-1 (IGF1) |
Reduce cellular senescence |
[125] |
Overexpression of miR-363-3p |
BM-MSC |
Target to tumor necrosis factor receptor-associated factor 3 (TRAF3) |
Promote BM-MSC osteogenic differentiation and suppresses osteogenic differentiation and senescence |
[126] |
Overexpression of miR-17 |
BM-MSC |
Target to the p53/miR-17/Smurf1 pathway |
Rescue the osteogenic differentiation of aged BM-MSC |
[127] |
Inhibition of miR-31a-5p |
BM-MSC |
Target to the SATB2/E2F2/RhoA pathway |
Modulate osteoclastic differentiation of aged MSC |
[128] |
Inhibition of miR-188 |
BM-MSC |
Target to HDAC9 and RICTOR |
Stimulate bone formation and decrease marrow fat accumulation in aged mice |
[52] |
Inhibition of miR-335 |
BM-MSC |
Target to AP-1 |
Rejuvenate aged mesenchymal stem cells |
[129] |
Inhibition of miR-1292 |
AD-MSC |
Target to FZD4 |
Regulate Senescence and Osteogenic Differentiation |
[109] |
Downregulation of lncRNA CYP7A1-1 |
BM-MSC |
Target to SYNE1 |
Rejuvenate aged BM-MSC |
[131] |
Overexpression of lncRNA HOTAIR |
BM-MSC |
Target to senescence-associated DNAm. |
Impact on proliferation and differentiation of MSC |
[132] |
Inhibition of lncRNA p21 |
BM-MSC |
Target to the Wnt/β-catenin signaling pathway |
Rejuvenate aged MSC |
[133] |
Overexpression of lncRNA Bmncr |
BM-MSC |
Target to the BMP2 pathway |
Alleviate bone loss and bone marrow fat accumulation |
[134] |
Overexpression of lncRNA miR22HG |
BM-MSC |
Target to the PTEN/AKT pathway |
Enhanced osteogenic differentiation of aged MSCs |
[135] |
CircRNA422 |
BM-MSC |
Target to the SP7/LRP5 axis |
Enhanced osteogenic differentiation of aged BM-MSCs |
[137] |
CircRNA hsa_circ_0074834 |
BM-MSC |
Target to the expression of ZEB1 and VEGF |
Enhanced osteogenic differentiation of aged BM-MSCs |
[138] |
CircRNA hsa_circ_0001485 |
BM-MSC |
Target to the TGFβ-BMP signaling pathway |
Enhanced osteogenic differentiation of aged BM-MSCs |
[139] |
Circ_0067680 |
BM-MSC |
Target to the Wnt/β-catenin signaling pathway |
Enhanced osteogenic differentiation of aged BM-MSCs |
[140] |
CircRNA-vgll3 |
AD-MSC |
Target to the circRNA-vgll3/miR-326-5p/ Itga5 pathway |
Enhances the osteogenic differentiation of aged AD-MSCs |
[141] |
CircFOXP1 |
AD-MSC |
Target to FOXP1 gene |
Bind to miR-33a-5p promotes osteogenic differentiation of aged AD-MSCs |
[142] |