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. 2023 Oct 1;14(5):1651–1676. doi: 10.14336/AD.2023.0208

Table 1.

Non-coding RNAs regulating MSC senescence.

Non-coding RNAs MSC type Target Effect Ref.
Inhibition of miR-195 BM-MSC Target to 3'-untranslated region of TERT gene Telomere relengthening [115]
Overexpression of miR-141-3p UCB-MSC Target to ZMPSTE24 Upregulate prelamin A [116]
Inhibition of miR-34a BM-MSC Target to TP53 Reduce ROS [117]
Inhibition of miR-155 BM-MSC Target to Bcl-2 associated BAG5 Enhance mitophagy [118]
Inhibition of miR-199a-5p AD-MSC Target to the SIRT1/AMPK signaling pathway Promotes autophagy and ameliorates MSC senescence [119]
Inhibition of miR-155-5p BM-MSC Target to the AMPK signaling pathway Rejuvenate aged MSC [28]
Overexpression of miR-10a BM-MSC Target to the BAX/Bcl-2 pathway Rejuvenate aged MSC and improved cardiac function [120]
Inhibition of miR-29c-3p BM-MSC Target to CNOT6 through p53-p21 and p16-pRB pathways Rejuvenate osteogenic differentiation capacity of senescent MSC [121]
Overexpression of miR-20b-5p/miR-106a-5p WJ-MSC Target to the p21/CDK/E2F1 pathway Promote cell proliferation, G1/S transition and DNA synthesis of MSC [122]
Inhibition of miR-196a BM-MSC Target to HOXB7 Improve proliferation and osteogenesis [123]
Overexpression of miR-130b BM-MSC Target to the ERK/FOXM1 pathway Against HG-induced MSC senescence [124]
Inhibition of miR-483-3p AD-MSC Target to insulin-like growth factor-1 (IGF1) Reduce cellular senescence [125]
Overexpression of miR-363-3p BM-MSC Target to tumor necrosis factor receptor-associated factor 3 (TRAF3) Promote BM-MSC osteogenic differentiation and suppresses osteogenic differentiation and senescence [126]
Overexpression of miR-17 BM-MSC Target to the p53/miR-17/Smurf1 pathway Rescue the osteogenic differentiation of aged BM-MSC [127]
Inhibition of miR-31a-5p BM-MSC Target to the SATB2/E2F2/RhoA pathway Modulate osteoclastic differentiation of aged MSC [128]
Inhibition of miR-188 BM-MSC Target to HDAC9 and RICTOR Stimulate bone formation and decrease marrow fat accumulation in aged mice [52]
Inhibition of miR-335 BM-MSC Target to AP-1 Rejuvenate aged mesenchymal stem cells [129]
Inhibition of miR-1292 AD-MSC Target to FZD4 Regulate Senescence and Osteogenic Differentiation [109]
Downregulation of lncRNA CYP7A1-1 BM-MSC Target to SYNE1 Rejuvenate aged BM-MSC [131]
Overexpression of lncRNA HOTAIR BM-MSC Target to senescence-associated DNAm. Impact on proliferation and differentiation of MSC [132]
Inhibition of lncRNA p21 BM-MSC Target to the Wnt/β-catenin signaling pathway Rejuvenate aged MSC [133]
Overexpression of lncRNA Bmncr BM-MSC Target to the BMP2 pathway Alleviate bone loss and bone marrow fat accumulation [134]
Overexpression of lncRNA miR22HG BM-MSC Target to the PTEN/AKT pathway Enhanced osteogenic differentiation of aged MSCs [135]
CircRNA422 BM-MSC Target to the SP7/LRP5 axis Enhanced osteogenic differentiation of aged BM-MSCs [137]
CircRNA hsa_circ_0074834 BM-MSC Target to the expression of ZEB1 and VEGF Enhanced osteogenic differentiation of aged BM-MSCs [138]
CircRNA hsa_circ_0001485 BM-MSC Target to the TGFβ-BMP signaling pathway Enhanced osteogenic differentiation of aged BM-MSCs [139]
Circ_0067680 BM-MSC Target to the Wnt/β-catenin signaling pathway Enhanced osteogenic differentiation of aged BM-MSCs [140]
CircRNA-vgll3 AD-MSC Target to the circRNA-vgll3/miR-326-5p/ Itga5 pathway Enhances the osteogenic differentiation of aged AD-MSCs [141]
CircFOXP1 AD-MSC Target to FOXP1 gene Bind to miR-33a-5p promotes osteogenic differentiation of aged AD-MSCs [142]