Table 1.
NBHO combined with Reperfusion Strategy. Experiments (NBHO + intravenous thrombolysis) were filled in purple, while experiments (NBHO+EVT) were filled in blank.
| Study Sponsor | Year | Study Type | Sample size | Type of patients | NBHO treatment and duration | Outcome | Efficacy |
|---|---|---|---|---|---|---|---|
| Shi et al. | 2017 | Cohort Stufy |
18 | Patients with acute ischemic stroke | Oxygen, 10L/min, 4 hours, by facemask | Blood Occludin and Claudin-5 Levels (baseline-24hours-72 h) NIHSS (1.3.7days) |
Beneificial |
| Li na | 2021 | Observational study | 227 (125+102) |
125 patients received NBHO therapy combined with intravenous thrombolysis, while 102 patients received intravenous thrombolysis only. | Oxygen, 10L/min, 4 hours, by facemask | mRS at 90 days | Beneificial |
| Cheng et al. | 2021 | Prospective RCT |
180 (91+89) |
stroke patients with large vessel occlusion | high-flow NBHO by a Venturi mask (FiO2 50%, flow 15 L/min) Starting After vessel recanalization for 6 h |
mRS at 90 days | Beneificial |
| Poli et al. | 2017 | Single-blind RCT |
456 | Patients with acute ischemic stroke due to large vessel occlusion likely to receive endovascular mechanical thrombectomy | 100% oxygen, ≥ 40 L/min, via a sealed non-rebreather facemask with reservoir | Ischemic core growth from baseline to 24 hours | On going |
| Li et al. | 2018 | Single-blind RCT |
86 | Patients with acute ischemic stroke who received endovascular treatment | Oxygen, 10L/min, via oxygen storage facemask | Cerebral infarct volume evaluated through MRI (DWI), 24-48 h after randomization | Beneificial |
| Li et al. | 2021 | triple-blind RCT |
280 | patients with indications for endovascular thrombectomy, who randomized<6 hours after stroke onset | 100% oxygen (≤30min after admission), 10L/min, 4 hours, by a sealed non-ventilating oxygen storage mask | mRS at 90 days | On going |
Abbreviations: NBHO, Normobaric Hyperoxia; NIHSS, the National Institute of Health Scale Score; RCT, Randomized Clinical Trial; mRS, modified Rankin Score; MRI, Magnetic Resonance Imaging; DWI, Diffusion Weighted Imaging.