Table 1.

NBHO combined with Reperfusion Strategy. Experiments (NBHO + intravenous thrombolysis) were filled in purple, while experiments (NBHO+EVT) were filled in blank.

Study Sponsor	Year	Study Type	Sample size	Type of patients	NBHO treatment and duration	Outcome	Efficacy
Shi et al.	2017	Cohort Stufy	18	Patients with acute ischemic stroke	Oxygen, 10L/min, 4 hours, by facemask	Blood Occludin and Claudin-5 Levels (baseline-24hours-72 h) NIHSS (1.3.7days)	Beneificial
Li na	2021	Observational study	227 (125+102)	125 patients received NBHO therapy combined with intravenous thrombolysis, while 102 patients received intravenous thrombolysis only.	Oxygen, 10L/min, 4 hours, by facemask	mRS at 90 days	Beneificial
Cheng et al.	2021	Prospective RCT	180 (91+89)	stroke patients with large vessel occlusion	high-flow NBHO by a Venturi mask (FiO2 50%, flow 15 L/min) Starting After vessel recanalization for 6 h	mRS at 90 days	Beneificial
Poli et al.	2017	Single-blind RCT	456	Patients with acute ischemic stroke due to large vessel occlusion likely to receive endovascular mechanical thrombectomy	100% oxygen, ≥ 40 L/min, via a sealed non-rebreather facemask with reservoir	Ischemic core growth from baseline to 24 hours	On going
Li et al.	2018	Single-blind RCT	86	Patients with acute ischemic stroke who received endovascular treatment	Oxygen, 10L/min, via oxygen storage facemask	Cerebral infarct volume evaluated through MRI (DWI), 24-48 h after randomization	Beneificial
Li et al.	2021	triple-blind RCT	280	patients with indications for endovascular thrombectomy, who randomized<6 hours after stroke onset	100% oxygen (≤30min after admission), 10L/min, 4 hours, by a sealed non-ventilating oxygen storage mask	mRS at 90 days	On going

Abbreviations: NBHO, Normobaric Hyperoxia; NIHSS, the National Institute of Health Scale Score; RCT, Randomized Clinical Trial; mRS, modified Rankin Score; MRI, Magnetic Resonance Imaging; DWI, Diffusion Weighted Imaging.