Table 1:

Epidemiologic subtypes of Kaposi sarcoma and their disease manifestations

	Disease Manifestations	Populations Impacted
Classic KS	Lesions on the skin and specifically occur in distal extremities. Rarer occurrence in mucus membranes, viscera or lymph nodes.	Middle aged to older men; Mediterranean or Central/Eastern European ancestry Cisgender men more commonly affected
Endemic KS	Nodular lesions typically affecting the lower extremities that can be aggressive. Lymphedema is common.	Individuals from sub-Saharan Africa Impacts adults and children
HIV-associated KS	Cutaneous involvement may occur over lower extremities, but can affect other parts of the body Visceral involvement, lesions may appear raised, discolored and/or ulcerated:  • Oral – hard and soft palate  • GI - lesions can be asymptomatic or present as nausea/vomiting, bleeding, weight loss  • Pulmonary - dyspnea, cough, or hemoptysis. Lymphedema is common	Persons living with HIV. Severity of disease may be related to underlying immunosuppression, with lower CD4 count associated with more sever disease.
Iatrogenic/Transplant- associated KS	Lesions are often localized to the skin with visceral organ involvement less commonly involved	Solid organ and hematopoietic stem cell transplant recipients
HIV-negative (non-epidemic KS)	Lesions limited to the skin that are localized Less associated with lymphedema	Younger, non-immunocompromised MSM