Table 2.
Baseline clinical characteristics in Chuvash erythrocytosis patients who developed a new thrombosis over 11 years of follow-up versus those who did not. Results in number (%) or median (interquartile range). Significance determined by the Fisher exact test for proportions and the Kruskal-Wallis test for continuous variables.
| New thrombosis | No new thrombosis | P* | |||
|---|---|---|---|---|---|
| N | result | N | result | ||
| Female gender | 33 | 15 (45.5%) | 122 | 67 (54.9%) | 0.43 |
| Age at baseline (years) | 33 | 42 (34-53) | 122 | 30 (19-44) | 0.0003* |
| Mean arterial pressure (mm Hg) | 33 | 91 (86-99) | 122 | 87 (80-96) | 0.036 |
| BMI | 33 | 22.4 (19.9-25.3) | 122 | 20.8 (19.1-23.0) | 0.025 |
| Smoking history, enrollment | 33 | 12 (36.4%) | 122 | 30 (24.6%) | 0.19 |
| History of phlebotomy therapy | 33 | 31 (93.9 %) | 122 | 75 (61.5%) | 0.002* |
| Past history of thrombosis | 33 | 15 (45.5%) | 122 | 12 (9.8%) | 0.00001* |
| White blood cells (x103/μL) | 32 | 5.0 (4.4-7.2) | 122 | 5.9 (4.7-7.0) | 0.28 |
| Hematocrit (%) | 32 | 52.2 (47.8-58.2) | 122 | 55.2 (49.3-59.6) | 0.23 |
| Mean corpuscular volume (fL) | 28 | 82.8 (74.2-90.1) | 108 | 82.2 (74.7-87.5) | 0.64 |
| Neutrophils | 22 | 2.7 (1.8-3.3) | 97 | 3.0 (2.3-3.8) | 0.28 |
| Platelets | 32 | 222 (161-289) | 122 | 226 (179-280) | 0.49 |
| Glucose (mg/dL) | 14 | 57.5 (47-75) | 46 | 54.1 (36-75) | 0.79 |
| Hb A1C(%) | 11 | 3.3 (2.9-3.8) | 39 | 3.3 (3.1-3.7) | 0.95 |
| Erythropoietin (IU/L) | 32 | 82.8 (39.1-115.4) | 111 | 38.9 (20.9-74.5) | 0.0008* |
| Ferritin (μg/L) | 32 | 12 (9-36) | 111 | 11 (7-20) | 0.3 |
| Transferrin (mg/dL) | 31 | 357 (325-385) | 109 | 402 (361-435) | 0.0002* |
| Fibrinogen (mg/dL) | 14 | 305 (222-400) | 59 | 285 (240-335) | 0.90 |
| Transferrin to fibrinogen molar ratio | 14 | 4.9 (4.1-6.2) | 57 | 5.9 (4.9-7.3) | 0.051 |
*
Significant after Bonferroni correction