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. Author manuscript; available in PMC: 2023 Sep 27.
Published in final edited form as: Cell Rep. 2023 Aug 1;42(8):112913. doi: 10.1016/j.celrep.2023.112913

Figure 3. Vasodilatory responses to glucose are impaired in islets from Aab+ and T1D donors.

Figure 3.

Living human pancreas slices were incubated with Lycopersicon esculentum lectin to label the islet microvasculature.

(A) Temporal projection showing changes in islet capillary diameter in a ND donor (nPOD6555) induced by 11 mM glucose.

(B and C) Quantification of capillary diameters in slices from ND (n = 37 capillaries/5 donors), Aab+ (n = 17 capillaries/3 donors), and T1D donors (n = 17 capillaries/5 donors). Each donor is shown with a different symbol.

(C) Mean ± SEM diameter values in 3G and 11G are shown. *p < 0.05 (paired t test).

(D) Quantification of average relative change in capillary diameter (Δdiameter; % baseline) induced by 11G for each group (dots: data point for each donor, bars: mean ± SEM). For each donor, responses from 3–11 vessels were recorded, and an average value was calculated.