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. Author manuscript; available in PMC: 2023 Nov 28.
Published in final edited form as: Cell. 2023 Aug 28;186(19):4100–4116.e15. doi: 10.1016/j.cell.2023.08.001

Figure 7. A model for epigenetic inheritance of unmethylated transposons.

Figure 7.

Active transposable elements (TEs) from male and female gametes are unmethylated and comprise MGH3 H2A and H3.3 H2A nucleosomes, respectively. In the zygote, H3.3 H2A nucleosomes are remodeled by DDM1 before replication, allowing deposition of H3.1 in S phase by CAF-1. Unwrapping of H3.1 H2A by DDM1 permits access to the methyltransferase MET1 allowing CG methylation. Subsequent incorporation of H2A.W stabilizes the nucleosome, possibly promoting H3K9 di-methylation (not shown) and CHG methylation by the chromomethylase CMT3. MGH3 H2A nucleosomes, inherited from pollen, are resistant to remodeling after fertilization. They are eventually replaced in the embryo by H3.3 H2A nucleosomes, but acetylation of histone H4 and other marks of active euchromatin prevent recognition by DDM1.