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X-ray structures of Mpro in complex with representative peptidomimetic covalent inhibitors. (a, c, e) The active site of Mpro (shown as an electrostatic surface) in complex with (a) 11a (PDB: 6LZE), (c) 13b (PDB: 6Y2G) and (e) nirmatrelvir (PDB: 7RFW); (b, d, f) The Mpro-inhibitor interactions for (b) 11a, (d) 13b and (f) nirmatrelvir. Hydrogen bonds are shown as yellow dashed lines.
