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. Author manuscript; available in PMC: 2024 Nov 15.
Published in final edited form as: Eur J Med Chem. 2023 Aug 28;260:115772. doi: 10.1016/j.ejmech.2023.115772

Figure 2.

Figure 2.

SARS-CoV-2 Mpro structure, substrates and mechanism of catalysis. (a) The homodimeric structure of SARS-CoV-2 Mpro (PDB: 6Y2G), with one monomer shown in cyan and the other in magentas. (b) The active site of Mpro-N3 complex (PDB: 6LU7), with Mpro shown as an electrostatic surface and N3 as a tube model with C atoms in green; (c) The Mpro-N3 interactions with hydrogen bonds shown as dashed lines. Cys145 forms a covalent bond with the inhibitor; (d) Sequences of the SARS-CoV-2 Mpro substrates; (e) Mechanism of catalysis for Mpro.