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. Author manuscript; available in PMC: 2024 Aug 1.
Published in final edited form as: Nat Chem Biol. 2023 Apr 20;19(8):1013–1021. doi: 10.1038/s41589-023-01321-6

Extended Data Figure 4 |. Alignments of RXFP1’s ECL2 with GPR52 and family A orthosteric agonists.

Extended Data Figure 4 |

Alignment of active-state RXFP1 (green, with ECL2 in magenta) (a), the β2 adrenergic receptor (gray) bound to adrenaline (purple; PDB ID: 4LDO)16 (b), and the angiotensin II type I receptor (gray) bound to the angiotensin II analog S1I8 (purple; PDB ID: 6DO1)17 (c), with GPR52 (gray with ECL2 in purple; PDB ID: 6LI3)18