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. Author manuscript; available in PMC: 2024 Oct 1.
Published in final edited form as: Brain Behav Immun. 2023 Jul 10;113:248–258. doi: 10.1016/j.bbi.2023.07.003

Figure 5: Novel object recognition performance with acute immune challenge at delayed timepoint.

Figure 5:

Three months after treatment cessation, PB-treated rats spent significantly less time with the novel object when challenged with acute LPS (Blue hatched bars) compared to their performance when challenged with saline (Open bars; Panel A). All animals traveled more during the LPS session relative to the saline session, with the Vehicle-RRS animals reaching significance (Panel B). There was no effect of treatment history or LPS on the total exploration time of any group (Panel C). All data are expressed as mean + SEM, n = 12–14/group. [**: Significant effect of LPS in PB-treated rats, p < 0.01. %: Significant effect of LPS in Vehicle-RRS rats, p < 0.01].