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. 2023 Sep 27;9(39):eadg9733. doi: 10.1126/sciadv.adg9733

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Fig. 6. — The cellular resource of bacteria is finite, and B. subtilis attempts to balance its proteome investment on biomass growth and survival. In another word, there exists a direct competition between growth trait and survival trait for the finite proteome resources in B. subtilis. Spo0A is a key regulator of the trade-off between growth and survival in B. subtilis. Compared with WT strain, spo0A-null strain has a lower investment on survival-related proteome but a higher investment on growth-related proteome; as a consequence, spo0A-null strain has a substantially higher exponential growth rate but a lower long-term fitness than its spo0A⁺ counterpart (WT strain or skfA sdp–null strain). In this sense, Spo0A is an important governor of the fitness trade-off between growth and survival in B. subtilis.